Candida albicans Interactions with Bacteria in the Context of Human Health and Disease

Humans are colonized by diverse populations of bacteria and fungi when in a healthy state and in the settings of disease, and the interactions between these microbial populations can be beneficial or detrimental to the host [1]. Among these microbial populations, Candida albicans is the fungus most commonly detected in association with humans [2], and numerous studies have described C. albicans interactions with its bacterial neighbors [1]. Here, with a focus on C. albicans, we provide examples of how bacterial-fungal interactions can influence human health. In addition, we highlight studies that give insight into the molecular mechanisms that govern the physical associations, interspecies communication, and changes in microbial behavior and survival that occur when bacteria and fungi occupy the same sites.